National Health Research Institutes

Secretary General's Office

Curriculum Vitae | Research | Patents | Publications | Members

Secretary General Chi-Ming Liang, Ph.D.

Curriculum Vitae

Education

• 1973-1977 Ph.D., Pharmacology, University of Arkansas for Medical Sciences
• 1971-1973 M.S., Chemistry, National Taiwan University
• 1966-1970 B.S., Pharmacy, National Taiwan University

Professional Experience

• 2006 - present Distinguished Investigator, National Health Research Institutes
• 2006 - present Adjunct professor, National Chung Hsing University
• 1997 - 2006 Research Fellow, Institute of Biological Chemistry, Academia Sinica.
• Director, Office of Public Affairs and Technology Transfer & Director, Incubation Center of Academia Sinica
• 1990 - 1994 Director, Molecular Immunology,Oncologix Inc
• 1987 - 1990 Acting Chief, Immunology Section, FDA, Bethesda
• 1986 - 1987 Senior Scientist, Biogen Research Corp
• 1982 - 1986 Head of Immunology, Biogen S.A., Geneva, Switzerland

Reviewer for Journals and Grant Applications

• Journal of Immunology
• Journal of Biological Chemistry
• FASEB Journal
• NIH Reproductive Biology SBIR Study Section

Research & Development

• My laboratory is primarily concentrating on exploring the biological functions and mechanism of action of biological active molecules for development of preventive and therapeutic medicines.
• Besides molecular and cellular biology studies, I also like to utilize my broad experience in immunology, pharmacology, biochemistry, regulatory affairs, project management of research and development as well as patent filing, licensing and marketing, to contribute to the build-up of biotechnology industry in Taiwan through focusing on profitable projects and establishment of a stream-line cooperation system among government institutes, universities and bio-pharmaceutical industry.

Patents

1. Liang, S.-M., Peng, J.-M., and Liang, C.-M., 2005 Apoptosis-inducing polypeptides. Application number US2005058654.
2. Johnston, P.G., Allegra, C.J., Chabner, B.A., and Liang, C.-M., 2001 Monoclonal antibodies specific for human thymidylate synthase. US 6221620.
3. Liang, C.-M., Turner, N.A., and Witiak, D.T. (1999) Treatment of vascular leakage and related syndrome such as septic shock by administration of matrix metalloproteinase inhibitors. US 5866570.
4. Liang, C.-M., Turner, N.A., and Witiak, D.T. (1993) Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors. WO9323075.
5. Liang, C.-M., Turner, N.A., and Witiak, D.T. (1993) Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors. AU4373993 9.
6. Johnston, P.G., Allegra, C.J., Chabner, B.A., and Liang, C.-M., (1992) Monoclonal antibodies specific for human thymidylate synthase. WO9219650.
7. Johnston, P.G., Allegra, C.J., Chabner, B.A., and Liang, C.-M., (1992) Monoclonal antibodies specific for human thymidylate synthase. CA2109086.

Publications

1. Kuo, C.-C., Liang, S.-M., Liang, C.-M., CpG-B ODN promotes cell survival via up-regulation of heat-shock protein 70. J. Biol. Chem. (in press).
2. Kuo, C.-C., Liang, C.-M., Lai, C.-Y., and Liang, S.-M., Heat-shock protein 90beta plays important role in CpG ODN-mediated toll-like receptor 9 signal pathway.J. Biol. Chem. (in revision).
3. Kim, S.-A., Liang, C.-M., Chiao, M.-T., Cheng, I.-C., Lee, F., Jong, M.-H., Tao, M.-H., Tseng, C.J., Yang, N.-S., and Liang, S.-M. DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity. J. Gene Med. (in press).
4. Kuo, C.-C., Lin, W.-T., Liang, C.-M., and Liang, S.-M., (2006) Class I and III phosphatidylinositol 3’-kinase play distinct roles in toll-like receptor signaling pathway. J. Immunol. 176: 5943-5949.
5. Shih, Y.-C., Liang, C.-M., and Barnard, R., (2006) Identification of success and failure factors for technology transfer in biotechnology – Case studies and surveys from Academia Sinica in Taiwan. The International Journal of Technology Transfer & Commercialisation5: 157-180.
6. Kuo, C.-C., Kuo, C.-W., Liang, C.-M., and Liang, S.-M., (2005) A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells. Proteomics 5, 894-906.
7. Peng, J.-M., Liang, S.-M., and Liang, C.-M. (2004) VP1 of foot-and-mouth disease virus induces apoptosis via akt signaling pathway. J. Biol. Chem. 279, 52168.
8. Hsieh, Y.-C., Liang, S.-M., Tsai, W.-L., Chen, Y.-H., Liu, D.T.-Y., and Liang, C.-M. (2003) Study of capsular polysaccharide from Vibrio parahaemolyticus. Infection and Immunity 71, 3329.
9. Wang, J.-H., Liang, C.-M., Shieh, J.-J., Jong, M.-H., Lin, Y.-L., Sieber, M., and Liang, S.-M., (2003) Induction of immunity in swine by purified recombinant VP1 of foot-and-mouth disease virus. Vaccine 21, 3721
10. Shieh, J.-J., Liang, C.-M., Chen C.-Y., Lee, F., Jong, M.-H., Lai, S.-S., and Liang, S.-M. 2001, Enhancement of the immunity to Foot-and-Mouth disease virus by DNA priming and protein boosting immunization.Vaccine 19, 4002-4010.
11. Ho, H.-Y., Cheng, M-L., Lu, F-J., Chou, Y.-H., Stern, A., Liang, C.-M., and Chiu, D. 2000,Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.Free Radical. Biol. & Med. 29, 156-169.
12. Cheng, M-L., Ho, H.-Y. Liang, C.-M., Chou, Y-H., Stern, A., Lu, F.-J., and Chiu, D. 2000, Cellular glucose-6-phosphate dehydrogenase (G6PD) status modulates the effects of nitric oxide (NO) on human foreskin fibroblasts. FEBS Letters 475, 257-262.
13. Pugin, J., Widmer, M.-C., Kossodo, S., Liang, C.-M., Prease, H.L., and Suffredini., A.F. 1999 Human Neutrophils secrete gelatinase B in vitro and in vivo response to endotoxin and proinflammatory mediators. Am. J. Respir. Cell. Mol. Biol. 20, 458-464.
14. Johnston, P.G., Allegra, C.J., Chabner, B.A., and Liang, C.-M., (1996) Monoclonal antibodies specific for human thymidylate synthase.AU 670912 (patent).
15. Visscher, D.W., Höythuyä, M., Ottosen, S.K. Liang, C.-M., Sarkar, F.H., Crissman, J.D., and Fridman, R. 1994 Enhanced expression of tissue inhibitor of metalloproteinase-2(TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence Int. J. Cancer 59, 339-344.
16. Höythuyä, M., Fridman, R., Komarek, D., porter-Jordan, K., Stetler-Stevenson, W.G., Liotta, L.A., and Liang, C.-M. 1994 Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int. J. Cancer 56, 500-505.
17. Bhat, M.K. Parkison, C., McPhie, P., Liang, C.-M., and Cheng, S.-Y. 1993 Conformational changes of human ß1 thyroid hormone receptor induced by binding of 3, 3’,5—triiodo-L-thyronine. Biochem. Biophy. Res. Commun. 195, 385-392.
18. Fridman R., Bird, R.E., Hoyhtya, M., Oelkuct, M., Lomarek, D., Liang, C.-M., Berman, M., Liotta, L., Stetler-Stevenson, W., and Furest, T. 1993 Expression of human recombinant 72 KD gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): Characterization of complex and free enzyme. Biochem. J. 289, 411-416.
19. Jiang, S.P., Hoyhtya, M., Bouffard, E., Fridman, R., Bird, R., and Liang, C.-M., 1993 Development of novel immunoassays to distinguish between the free and complexed forms of matrix metalloproteinase-2(MMP-2) FASEB J. 7.1211.
20. Liang, C.-M., and Liang, S.-M. 1993 How to apply and obtain license for biologics from FDA of U.S.A. (Ed. Chin-Tze Peng) CCNAA Science Division, Washington D.C.
21. Liang, S.-M., Lee, N., Chen, Y.Y. and Liang, C.-M. 1992 Glutathione regulates the expression and turnover of interleukin-2 receptors. Cell. Immunol. 144, 131-142.
22. Ting, C.-C., Hargrove, M.E., Liang, S.-M., Liang, C.-M., and Sharrow, S.O. 1992 Dichotomy of glutathione regulation of the activation of resting and preactivated lymphocytes. Cell. Immunol. 142, 40-53.
23. Liang, S.-M., Lee, N., Finbloom, D.S., and Liang, C.-M. 1992 Regulation by glutathioner of interleukin-4 activity on cytotoxic T-cells. Immunol. 75, 435-440.
24. Johnston, P.G., Liang, C.-M., Henry, S., Chabner, B.A., and Allegra, C.J. 1991 Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human-cell and tissue. Cancer Res. 51, 6668-6676.
25. Ashizawa, K., Willingham, M.C., Liang, C.-M., and Cheng, S.-Y. 1991 In vivo regulation of monomer-tetramer conversion of pyruvate kinase, subtype M2 by glucose. J. Biol. Chem. 266, 16842-16846.
26. Lin, K.-H., Willingham, M.C., Liang, C.-M., and Cheng, S.-Y. 1991 Intracellular distribution of the endogenous and transfected ßform of thyroid hormone nuclear receptor visualized by the use of domain-specific monoclonal antibodies. Endocrinol. 128, 2601-2609.
27. Liang, S.-M., Liang, C.-M., Hargove, M.E., and Ting, C.-C. 1991 Regulation by glutathione of the effect of lymphokine(s) on differentiation of primary activated lymphocytes: Influence of glutathione on cytotoxic activitiy of CD3-AK. J. Immunol. 146, 1909-1913.
28. Liang, C.-M., and Liang, S.-M. 1991 Relationship between glutathione and interleukin-2 dependency of cytotoxic T cells. J. Cellular Biochem. Suppl. 15F, 134.
29. Hargrove, M.E., Liang, S.-M., Liang, C.-M., and Ting, C.C. 1991 Dichotomy in glutathione(GSH) regulation of lymphocyte-activation. FASEB J. 5, 1342.
30. Liang, S.-M., Liang, C.-M., Hargrove, M.E., and Ting, C.-C. 1991 Interrelationships of glutathione, lymphokines, and differentiation of primary lymphocytes, J. Cellular Biochem. Suppl. 15F, 75.
31. Liang, C.-M., Henry, S., Liang, S.-M., and Epstein, J.S. 1990 An anti-p24 monoclonal antibody shows cross-reactivity with multiple HIV-1 proteins. J. Immunol. Methods 132, 57-62.
32. Pepinsky, R.B., Sinclair, L.K., Douglas, I., Liang, C.-M., Lawton, P., and Browning, J.L. 1990 Monoclonal antibodies of Lipocortin-1 as probes for biological function. FEBS Lett. 261, 247-252.
33. Hargrove, M.E., Liang, S.-M., Liang, C.-M., and Ting, C.-C. 1990 Regulation by glutathione of the activation of aCD-3induced activated killer cells(CD3-AK). Proc. Amer. Assoc. Cancer Res., 31, 267.
34. Liang, C.-M., Epstein, J., Lee, N., and Liang, S.-M., Regulation of the expression and turnover of interleukin-2-receptors by glutathione. J. Cellular Biochem. Suppl., 14B, 36.
35. Liang, S.-M., Lee, N. Finbloom, D., and Liang, C.-M., 1990 The effect of glutathione on the binding and internalization of IL-4. J. Cellular Biochem. Suppl., 14B, 25.
36. Liang, S.-M., Liang, C.-M., and Chiueh, C.C. 1989 Visualization of intereukin-2-like molecules in MP+ -lesioned rat brain. Biochem. Biophys. Res. Commun. 165, 1312-1318.
37. Liang, C.-M., Lee, N., Cattell, D., and Liang, S.-M. 1989 Glutathione regulates interleukin-2 activity on cytotoxic T-cells. J. Biol. Chem. 264, 13519-13523.
38. Obata, T., Fujuda, T., Willingham, M.C., Liang, C.-M., and Cheng, S. 1989 A cytoplasmic thyroid hormone binding protein: Characterization using monoclonal antibodies, Biochem. 28, 617-623.
39. Liang, S.-M., Lee, N., Cattell, D., and Liang, C.-M. 1989 Regulation of the binding and internalization of IL-2 by glutathione, J. Cellular Biochem. Suppl. 130, 75.
40. Liang, S.-M., Lee, N., Cattell, D., and Liang, C.-M. 1989 Augumentation of binding and internalization of IL-2 in murine lymphocytes by thiol compounds, 7th International Congress of Immunology, p. 301.
41. Liang, C.-M., Shih, J., Alter, J. H., Geyer, S., and Epstein, J. 1988 Analysis of glutathione levels in whole blood of HIV-seropositive persons. IV Internatl. Conf. On AIDS 2, 2602.
42. Liang, S.-M., Lee, N., Zoon, K.C., Manischewitz, J.F., Chollet, A., Liang, C.-M., and Quinnan, G.V. 1988 Biological characterization of human interleukin-2 mutant proteins. J. Biol. Chem. 263, 4768-4772.
43. Liang, S.-M., Zoon, K.C., Siegel, J.P., Manische, J.F., Enterlin, J., Liang, C.-M., and Guinnan, G.V. 1988 Evaluation of biological activities of mutant human interleukin-2 proteins. FASEB J. 2, 1247.
44. Gualtieri, R.J., Liang, C.-M., Shadduck, R.K., Waheed, A., and Banks, J. 1987 Identification of hematopoietic growth factors elaborated by bone marrow stromal cells using antibody neutralization analysis. Exp. Hematol. 15, 883-889.
45. McGrath, H.E., Liang, C.-M., Alberico, T.A., and Quesenberry, P.J. 1987 The effect of lithium on growth factor production in long-term bone marrow cultures. Blood 70, 1136-1142.
46. Alberico, T.A., Ihle, J.N., Liang, C.-M., McGrath, H.E., and Quesenberry, P.J. 1987 Stromal growth factor-production in irradiated lectin exposed long-term murine bone marrow cultures. Blood 69, 1120-1127.
47. Ware, C.F., Green, L.M., Reade, J.L., Develin, P.E., Liang, C.-M., and Develin, J.J. 1986 antigenic characterization of cytotoxic lymphokines produced by cloned himan T cell lines. in UCLA symposium Vol.45, Membrane-mediated cytotoxicity pp. 389-400, Alan R. Liss, Inc.
48. Green, L.M., Reade, J.L., Ware, C.F., Develin, P.E., Liang, C.-M., and Develin, J.J. 1986 Cytotoxic lymphokines produced by cloned human cytotoxic T lymphocytes, J. Immunol. 137, 3488-3493.
49. Romagnani, S., Giudize, M.G., Biagiotti, R., Almerigogna, F., Mingari, C., Maggi, E., Liang, C.-M., and Moretta, L. 1986 B cell growth factor activity of interfreron-gamma: recombinant human interferon-gamma promotes proliferation of anti-mu-activated human B lymphocytes. J. Immunol. 136, 3513-3516.
50. Recomagnani, S., Giudize, G.M., Almerigogna, F., Biagiotti, R., Alessi, A., Mingari, C., Liang. C.-M., Moretta, L., and Ricci, M. 1986 Analysis of the role of interferon-gamma, interleukin-2 and a third factor distinct from interferon-gamma and interleukin-2 on human B cell proliferation. Evidence that they act at different times after B cell activation. Eur. J. Immunol. 16, 623-629.
51. Liang, C.-M., Liang, S.-M., Jost, T., Sand, A. Dougas, I, and Allet, B. 1986 Production and characterization of monoclonal antibodies against recombinant human tumor necrosis factor/cachectim. Biochem. Biophys. Res. Commun. 137, 847-854.
52. Liang, S.-M., Thatcher, D., Liang, C.-M., and Allet, B. 1986 Studies of Structure-activity relationships of human interleukin-2. J. Biol. Chem. 261, 334-337.
53. Liang, C.-M., Herren, S., Sand, A., and Jost, T. 1985 Study of antigenic epitopes recognized by monoclonal antibodies of recombinant interferon-gamma. Biochem. Biophys. Res. Commun. 128, 171-178.
54. Liang, C.-M., Herren, S., Fountoulakis, M., Otto, B., Hirschi, M., Gutzwiller, E., and Gerlis, L. 1985 Analysis of antibody response in patients receiving recombinant E. coli derived human interferon-gamma. Clinical Immunol. Immunopathol. 36, 95-100.
55. Delamarter, J.F., Mermod, J.-J., Liang, C.-M., Eliason, F.F., and Thatcher, D. 1985 Recombinant murine GM-CSF from E. Coli has biological activity and is neutralized by a specific antiserum. EMBO J. 4, 2575-2581.
56. Van der Burg, M.E.L., Edelstein, M., Gerlis, L., Liang, C.-M., Hirschi, M., and Dawason, A. 1985 Recombinant interferon-gamma (Immuneron):results of a phase I trial in patients with cancer. J. Biol. Resp. Modif. 4, 264-272.
57. Liang, S.-M., Allet, B., Rose, K., Hirschi, M., Liang, C.-M., and Thatcher, D. 1985 Characterization of human interleukin-2 derived from E. coli. Biochem. J. 229, 429-439.
58. Sobol, S.l., Liang, C.-M., Dandekar, S., and Kranzler, L.S. 1983 In vitro biosynthesis and processing of immunologically identified methionine-enkephalin precursor protein, J. Biol. Chem. 258, 2697-2703.
59. Liang, C.-M., Donehower, R.C., and Chabner, B.A. 1982 Biochemical interactions between N-(phosphonacetyl)-L-aspartate (PALA) and 5-fluorouracil (FU). Mol. Pharmacol. 21, 224-228.
60. Liang, S.-M., Liang, C.-M., and Liu, T.Y. 1981 Studies on Limulus amoebocyte: Isolation and identification of a membrane-bound protein activator of cyclic nucleotide phosphodiesterase from Liumulus amoebocyte. J. Biol. Chem. 256, 4968-4972.
61. Liang, C.-M., Liu, Y.-P., and Chabner, B.A. 1980 Modes of action of hypoxanthine, inosine, inosine 5’-monophosphate on cyclic nucleotide phosphodiesterase from bovine brain. Biochem. Pharmacol. 29, 277-282.
62. Liang, C.-M., Liu, Y.-P., and Chabner, B.A. 1979 Isolation and identification of a small molecular weight inhibitor of cyclic nucleotide phosphodiesterase from bovine brain. Biochem. Biophys. Acta 571, 63-69.
63. Liang, C.-M., Flacke, W.E., and Hardwick, B. 1976 Differential influence of dopamine on ganlionic nicotinic and muscarinic transmission. Pharmacol. 18, 226.
64. Chen, F.C., Lin, Y.-M., and Liang, C.-M. 1974 Biflavonyls from dupes of Rhus Succedanea, Phytochem. 13, 276-278.

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