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Cancer Clinical Trials
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Historical Events
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Taiwan Cooperative Oncology Group (TCOG)

Cancer Clinical Trials

On-going Clinical Trials 

New Trials Started in Future

Finished Clinical Trials 


On-Going Clinical Trials (~ Dec. 2015)

No. Protocol PI Date Activated Expected Cases Entered Cases
T3212 The Clinical Significance of Bio-markers in Pancreatic Cancer Patients. Hui-Ju Ch’ang, 
Li-Tzong Chen
2012.12 ~ now 270 166
T2312 The Effect of EGCG on Virus Reactivation in Post- radiation NPC Patients without Detectable EBV DNA. Jin-Ching Lin,  
Jen-Yang Chen,    
Sen-Tien Tsai
2013.4 ~ now 352 199
T2212 Randomized Two Arms Phase II Study of Induction Chemotherapy Followed by CCRT in Locally Advanced Pancreatic Cancer. Hui-Ju Ch’ang, 
Yen-Shen Shen
2013.7 ~ now 86 19
T1214 Multi-center Registration Study for Gastroentero- Pancreatic NET in Taiwan Li-Tzong Chen, 
Yen-Shen Shen,
Hui-Jen Tsai
2014.1 ~ now 600 291
T1313 Phase III Trial in NPC with Post- radiation Detectable Plasma EBV DNA. Jin-Ching Lin 2014.12 ~ now 147 2
T2214 First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCL. Sung-Hsin Kuo, 
Li-Tzong Chen
2015.4 ~ now 30 3
TG1308 S-1 in Combination with Gemcitabine for Patients with Advanced Biliary Tract Cancer. Li-Tzong Chen 2015.5 ~ now 46 40
T1Z14 Phase II Study of TLC388 as Second-line Treatment for poorly-differentiated NET Patients. Yee Chao, 
Ming-Huang Chen, 
Hui-Jen Tsai
2015.7 ~ now 44 6
T3214 Phase II Trial of LDK378 as Therapy in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma. Li-Tzong Chen, 
Yen-Shen Shen,  
 Nai-Jung Chiang
2015.9 ~ now 31 1
T1914 Molecular Features Underlying Ethnic Differences in Survival of CLL Patients in Taiwan. Hwei-Fang Tien, 
Shang-Ju Wu
2015.11 ~ now 250 4

 New Trials Started in Future


Finished Clinical Trials

No. Protocol PI Date Activated Entered Cases
T1188 Phase II Study of Weekly CAF for Advanced Breast Cancer. Wei-Shou Hwang 1988.10 ~ 1994.12 107
T1488 Prospective Study of T and B Cell NHL by Using CHOP. Ann-Lii Cheng 1988.9 ~ 1994.12 213
T1788 Phase II Trial of VIP in Advanced Soft Tissue Sarcoma. Wei-Shou Hwang 1988.7 ~ 1994.12 90
T1592 Evaluation of Dose Optimization of Carboplatin for SCLC. Jang-Yang Chang 1992.2 ~ 1995.5 40
T1394 Phase III Study of R/T vs. CCRT in Advanced NPC. Kwan-Hwa Chi 1994.11 ~ 1999.7 158
T1495 Phase III Study of Steroid-containing vs. Steroid-free Chemotherapy for HBV Carriers with Non-Hodgkin's Lymphoma. Ann-Lii Cheng, 
Pei-Jer Chen
1995.11 ~ 2000.5 50
T1296 Eradication of HP in the Management of Low-grade MALToma. Li-Tzong Chen 1996.3 ~ 1999.4 41
A1293 Gastric Adenocercinoma Registry in Surgery and Pathology. Chew-Wun Wu 1998.6 ~ 2000.12 1404
T1297 Phase III Adjuvant IFN vs Conservative Tx for Post OP HCC. Li-Tzong Chen, 
Pei-Jer Chen
1997.10 ~ 2003.4 268
T1899 HPV Survey in CIN for LSIL Cases. Tang-Yaun Chu,   
Chi-An Chen, 
Tzer-Ming Chen
1999.8 ~ 2004.2 1331
T2201 Phase III Study in PostOP Adjuvant CCRT for Stage III & IVa Adeno- carcinoma of Stomach. Jang-Yang Chang 2001.4 ~ 2004.3 14
T1E01 PostOP Adjuvant Therapy for Stage Ib-IIa Cervical Carcinoma with Pelvic LN Meta. Chyong-Huey Lai 2002.2 ~ 2004.3 4
T1802 Phase II THADO for Prostate Cancer. Ruey-Kuen Hsieh 2002.10 ~ 2004.7 30
T3202 Phase II Palliative C/T for Biliary Tract Cancer. Chiun Hsu 2002.7 ~ 2004.9 50
T2399 Phase III Adjuvant CCRT for High-risk Oral Cavity Cancer. Mow-Ming Hsu, 
Ruey-Long Hong
1999.8 ~ 2004.11 161
T1401 Phase III Oral Anti-HBV Prophylaxis for HBV Carrier with Non-Hodgkin's Lymphoma. Ann-Lii Cheng, 
Pei-Jer Chen
2001.10 ~ 2005.4 52
HNPCC Heritable Colorectal Cancer Registry. Reiping Tang 2002.5 ~ 2006.12 817
T1399 Phase III Chemoprevention Tx vs Placebo for Oral Cavity Cancer. Mow-Ming Hsu, 
Ruey-Long Hong
1999.4 ~ 2005.7 342
T2202 Phase III Thado vs Placebo for Advanced HCC. Li-Tzong Chen 2003.2 ~ 2007.7 16
T1202 Phase II Adjuvant C/T for High-risk Colon Cancer. Tsai-Shen Yang 2002.4 ~ 2008.1 162
T1204 Phase II Induction C/T + CCRT for Locally Advanced Pancreatic Cancer. Hui-Ju Ch’ang, 
Li-Tzong Chen
2004.11 ~ 2008.8 50
T1303 Phase III Induction C/T +CCRT vs CCRT for Stage IV NPC. Ruey-Long Hong, 
Mow-Ming Hsu, 
Cheng-Hsu Wang
2003.8 ~ 2009.8 480
T1405 Phase II CCRT for NK T-cell Lymphoma. Ming-Chih Chang 2006.5 ~ 2009.9 33
T1406 Phase II High Dose MTX + Steroid and Whole Brain R/T with Temozolomide for CNS Lymphoma. Ching-Hung Lin,  
Ann-Lii Cheng
2006.11 ~ 2009.10 4
T1706 Phase II C/T with Gemcitabine & Docetaxel for Soft Tissue Sarcoma or GI Stromal Tumor. Chung-Huang Chan 2006.12 ~ 2010.1 58
T1209 Phase I/II sorafenib + thalidomide in HCC. Chung-Huang Chan 2009.8 ~ 2010.1 3
T1206 Phase III Adjuvant Oral Anti-HBV Tx for Post OP HCC. Li-Tzong Chen,  
Pei-Jer Chen
2007.4 ~ 2010.8 117
T1309 Phase II Study of Neoadjuvant Bio-C/T with CPC Followed by Bio-R/T in High-risk OSCC. Jang-Yang Chang,  
Sen-Tien Tsai
2009.9~2011.5 47
T2207 Phase II Trial Celecoxib with PreOP CCRT for Locally Advanced Rectal Cancer. Ling-Wei Wang 2007.7 ~ 2011.6 55
T1210 Randomized Phase II Study of GEMOX With or Without Cetuximab in BTC. Li-Tzong Chen 2010.12 ~ 2012.5 122
T1306 Phase II/III Adjuvant Anti-Angiogenesis Tx for High-risk Oral Cavity Cancer. Ruey-Long Hong 2007.5 ~ 2012.12 150
T2209 Phase II Randomized Study of C/T Followed by CCRT in Locally Advanced Pancreatic Cancer. Hui-Ju Ch’ang,  
Yan-Shen Shan
2009.11 ~ 2013.1 15
T3211 Phase II Study Using Genetic Polymorphisms of Drug in Patients with Gastric Cancer. Yee Chao, 
Ming-Huang Chen
2012.3 ~ 2014.11 51
T2211  Phase II Study of Weekly AUY922 for Advanced GIST. Li-Tzong Chen, 
Nai-Jung Chiang
2011.10 ~ 2015.2  30
T3206  Phase II Triple-Treatment for Low & High Grade MALToma.  Li-Tzong Chen 2006.10 ~ 2015.5 47 
T3207 Phase III Adjuvant Gemcitabine vs. Gemcitabine + CCRT in Pancreatic Cancer. Tsann-Long Hwang,  
Hui-Ju Ch’ang
2009.2 ~ 2015.7
T1211 Phase I/II Trial of SLOG Therapy in Metastatic Pancreatic Cancer. Li-Tzong Chen,  
Kun-Chih Tsai
2012.4 ~ 2015.12 73


  1. T1188-“Weekly CAF Chemotherapy for Advanced Breast Cancer Patients”. Hwang WS, Hsiung CA, Ko WS, Wang CC, Chang JY, Lai GM, Hsieh RK, Tsao CJ, Chen LT, Law CK, Cheng AL, Fan SF, Tzeng CH, Chiou TJ, Whang-Peng J. Oncology. 1997 Jul-Aug; 54(4):293-7.
  2. T1394-“A Phase III Study of Adjuvant Chemotherapy in Advanced Nasopharyngeal Carcinoma Patients”. Chi KH, Chang YC, Guo WY, Leung MJ, Shiau CY, Chen SY, Wang LW, Lai YL, Hsu MM, Lian SL, Chang CH, Liu TW, Chin YH, Yen SH, Perng CH, Chen KY. Int J Radiat Oncol Biol Phys. 2002 Apr 1; 52(5):1238-44.
  3. T1495-“Steroid-Free Chemotherapy Decreases Risk of Hepatitis B Virus (HBV) Reacti-vation in HBV-carriers with Lymphoma”. Cheng AL, Hsiung CA, Su IJ, Chen PJ, Chang MC, Tsao CJ, Kao WY, Uen WC, Hsu CH, Tien HF, Chao TY, Chen LT, Whang-Peng J; Lymphoma Committee of TCOG. Hepatology. 2003 Jun; 37(6): 1320-8.
  4. T1495-“Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients”. Su WP, Wen CC, Hsiung CA, Su IJ, Cheng AL, Chang MC, Tsao CJ, Kao WY, Uen WC, Hsu C, Hsu CH, Lu YS, Tien HF, Chao TY, Chen LT, Whang-Peng J, Chen PJ. World J Gastroenterol. 2005 Sep 14; 11(34):5283-8.
  5. T1296-“Long-Term Results of Anti-helicobacter pylori Therapy in Early-stage Gastric High-grade Transformed MALT Lymphoma”. Chen LT, Lin JT, Tai JJ, Chen GH, Yeh HZ, Yang SS, Wang HP, Kuo SH, Sheu BS, Jan CM, Wang WM, Wang TE, Wu CW, Chen CL, Su IJ, Whang-Peng J, Cheng AL. J Natl Cancer Inst. 2005 Sep 21; 97(18):1345-53.
  6. T1296-“Nuclear Expression of BCL10 or Nuclear Factor Kappa B Helps Predict Helicobacter Pylori-independent Status of Low-grade Gastric Mucosa-associated Lymphoid Tissue Lymphomas with or without t(11;18)(q21;q21)”. Yeh KH, Kuo SH, Chen LT, Mao TL, Doong SL, Wu MS, Hsu HC, Tzeng YS, Chen CL, Lin JT, Cheng AL. Blood. 2005 Aug 1; 106(3):1037-41.
  7. T1899-“Epidemiologic Correlates of Cervical Human Papillomavirus Prevalence in Women with Abnormal Pap Smear Tests: A Taiwan Cooperative Oncology Group (TCOG) Study”. Sun CA, Hsiung CA, Lai CH, Chen CA, Chou CY, Ho CM, Twu NF, Feng WL, Chuang MH, Hsieh CY, Chu TY. J Med Virol. 2005 Oct; 77(2):273-81.
  8. T1899-“The Distribution and Differential Risks of Human Papillomavirus Genotypes in Cervical Preinvasive Lesions: A Taiwan Cooperative Oncologic Group (TCOG) Study”. Chen CA, Liu CY, Chou HH, Chou CY, Ho CM, Twu NF, Kan YY, Chuang MH, Chu TY, Hsieh CY; Taiwan Cooperative Oncologic Group. Int J Gynecol Cancer. 2006 Sep-Oct; 16(5):1801-8.
  9. T1899 LAB-“Human Papillomaviral Load Changes in Low-grade Squamous Intraepithelial Lesions of the Uterine Cervix”. Ho CM, Cheng WF, Chu TY, Chen CA, Chuang MH, Chang SF, Hsieh CY. Br J Cancer. 2006 Nov 20; 95(10):1384-9.
  10. T1401-“A Revisit for Prophylactic Lamivudine for Chemotherapy-associated Hepatitis B Reactivation in Non-Hodgkin's Lymphoma: a Randomized Trial”. Hsu C, Hsiung CA, Su IJ, Hwang WS, Wang MC, Lin SF, Lin TH, Hsiao HH, Young JH, Chang MC, Liao YM, Li CC, Wu HB, Tien HF, Chao TY, Liu TW, Cheng AL and Chen PJ. Hepatology, 2008 Mar; 47(3):844-53.
  11. T1204-“Induction chemotherapy with gemcitabine, oxaliplatin, and 5-Fluorouracil/ Leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study”. Ch'ang HJ, Lin YL, Wang HP, Chiu YF, Chang MC, Hsu CH, Tien YW, Chen JS, Hsieh RK, Lin PW, Shan YS, Cheng AL, Chang JY, Whang-Peng J, Hwang TL, Chen LT. Int J Radiat Oncol Biol Phys. 2011 Dec 1; 81(5):e749-57.
  12. T1309-“A Phase II Study of Neoadjuvant Bio-chemotherapy with Cetuximab, Paclitaxel, and Cisplatin (CPC) Followed by Cetuximab-based Concurrent Bio-radiotherapy in High-risk Locally Advanced Head and Neck Cancer – Representative of Head and Neck Cancer Study Group of Taiwan Cooperative Oncology Group”. Chang KY, Yen CJ, Hsieh CY, Tsou HH, Chiu CF, Chen CC, Tsao CJ, Tsai KY, Tsai ST, Chang JY. E ur J Cancer. 2011; 47:S547-S548.
  13. T1297-“Long-term Results of a Randomized, Observation-controlled, Phase III Trial of Adjuvant Interferon Alfa-2b in Hepatocellular Carcinoma after Curative Resection”. Chen LT, Chen MF, Li LA, Lee PH, Jeng LB, Lin DY, Wu CC, Mok KT, Chen CL, Lee WC, Chau GY, Chen YS, Lui WY, Hsiao CF, Whang-Peng J, Chen PJ; Disease Committee of Adjuvant Therapy for Postoperative Hepatocellular Carcinoma, TCOG, NHRI. Ann Surg. 2012 Jan; 255(1):8-17.
  14. T2207-“Celecoxib plus Chemoradiotherapy for Locally Advanced Rectal Cancer: A Phase II TCOG Study”. Wang LW, Hsiao CF, Chen WT, Lee HH, Lin TC, Chen HC, Chen HH, Chien CR, Lin TY, Liu TW. J Surg Oncol. 2014 May; 109(6):580-5.
  15. T1408-“Chemotherapy-Induced Hepatitis B Reactivation in Lymphoma Patients with Resolved HBV Infection: A Prospective Study”. Hsu C, Tsou HH, Lin SJ, Wang MC, Yao M, Hwang WL, Kao WY, Chiu CF, Lin SF, Lin J, Chang CS, Tien HF, Liu TW, Chen PJ, Cheng AL; Taiwan Cooperative Oncology Group. Hepatology. 2014 Jun; 59(6):2092-100.
  16.  T1405-“Long-term Results of A Phase II Trial with Frontline Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy for Localized Nasal Natural Killer/T-cell Lymphoma”. Tsai HJ, Lin SF, Chen CC, Chen TY, Su WC, Hwang WL, Lin JC, Chiou TJ, Kao WY, Chiu CF, Chang YF, Chang SM, Chang MC, Su IJ. Eur J Haematol. 2015 Feb; 94(2):130-7.
  17. T1210-“A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer”. Chen JS; Hsu C; Chiang NJ; Tsai CS; Tsou HH; Huang SF; Bai LY; Chang IC; Shiah HS; Ho CL; Yen CJ; Lee KD; Chiu CF; Rau KM; Yu MS; Yang Y; Hsieh RK; Chang JY; Shan YS; Chao Y; Chen LT, on behalf of the TCOG. Annals Oncology. 2015 May; 26(5):943-9.
  18. T1394-“Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncology”. Blanchard P, Lee A, Marguet S, Leclercq J, Ng WT, Ma J, Chan TC, Huang PY, Benhamou E, Zhu G, Chua TT, Chen Y, Mai HQ, Kwong LW, Cheah SL, Moon J, Tung Y, Chi KH, Fountzilas G, Zhang L, Hui P, Lu TX, Bourhis J, Pignon P, on behalf of the MAC-NPC Collaborative Group. 2015 Jun; 16:645-55.

  <Updated on Jan. 26, 2016>



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